Responses of pallidal neurons to striatal stimulation in monkeys with MPTP-induced parkinsonism
Identifieur interne : 004B29 ( Main/Exploration ); précédent : 004B28; suivant : 004B30Responses of pallidal neurons to striatal stimulation in monkeys with MPTP-induced parkinsonism
Auteurs : L. Tremblay ; M. Filion ; P. J. BedardSource :
- Brain research [ 0006-8993 ] ; 1989.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Singe.
English descriptors
- KwdEn :
- Action Potentials (drug effects), Animals, Apomorphine (pharmacology), Basal ganglion, Brain, Caudate nucleus, Central nervous system, Corpus Striatum (physiopathology), Corpus striatum, Dopamine, Electric Stimulation, Electrical stimulus, Globus Pallidus (drug effects), Globus Pallidus (physiopathology), MPTP Poisoning, Macaca fascicularis, Monkey, Neurotoxin, Pallidum, Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (physiopathology), Parkinson disease, Putamen, Unit response.
- MESH :
- chemical , pharmacology : Apomorphine.
- chemically induced : Parkinson Disease, Secondary.
- drug effects : Action Potentials, Globus Pallidus.
- physiopathology : Corpus Striatum, Globus Pallidus, Parkinson Disease, Secondary.
- Animals, Electric Stimulation, MPTP Poisoning, Macaca fascicularis.
Abstract
Extracellular single unit activity was recorded from neurons of the internal and external pallidal segments, and from «border cells» (Bor) which are part of the nucleus basalis, in 2 cynomolgus monkeys rendered parkinsonian by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). Cell counts showed that at least 90% of the nigral neurons of the compacta-type were degenerated. Electrical stimulation was applied to 3 sites bilaterally in the striatum; one in the caudate nucleus and 2 in the putamen. The results were compared to those obtained in intact monkeys. In the parkinsonians, more neurons of the 3 types responded to ipsilateral stimulation. The difference was even greater for contralateral responses, except in the case of Bor neurons. Greater proportions of the 3 types of neurons also responded to 2 and 3 sites and showed convergent responses to both the caudate nucleus and the putamen
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 001193
- to stream PascalFrancis, to step Curation: 000D34
- to stream PascalFrancis, to step Checkpoint: 001085
- to stream Main, to step Merge: 005482
- to stream PubMed, to step Corpus: 001C12
- to stream PubMed, to step Curation: 001C12
- to stream PubMed, to step Checkpoint: 001C12
- to stream Ncbi, to step Merge: 002161
- to stream Ncbi, to step Curation: 002161
- to stream Ncbi, to step Checkpoint: 002161
- to stream Main, to step Merge: 005348
- to stream Main, to step Curation: 004B29
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Responses of pallidal neurons to striatal stimulation in monkeys with MPTP-induced parkinsonism</title><author><name sortKey="Tremblay, L" sort="Tremblay, L" uniqKey="Tremblay L" first="L." last="Tremblay">L. Tremblay</name></author><author><name sortKey="Filion, M" sort="Filion, M" uniqKey="Filion M" first="M." last="Filion">M. Filion</name></author><author><name sortKey="Bedard, P J" sort="Bedard, P J" uniqKey="Bedard P" first="P. J." last="Bedard">P. J. Bedard</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">90-0226454</idno><date when="1989">1989</date><idno type="stanalyst">PASCAL 90-0226454 INIST</idno><idno type="RBID">Pascal:90-0226454</idno><idno type="wicri:Area/PascalFrancis/Corpus">001193</idno><idno type="wicri:Area/PascalFrancis/Curation">000D34</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001085</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001085</idno><idno type="wicri:doubleKey">0006-8993:1989:Tremblay L:responses:of:pallidal</idno><idno type="wicri:Area/Main/Merge">005482</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:2790469</idno><idno type="wicri:Area/PubMed/Corpus">001C12</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001C12</idno><idno type="wicri:Area/PubMed/Curation">001C12</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001C12</idno><idno type="wicri:Area/PubMed/Checkpoint">001C12</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001C12</idno><idno type="wicri:Area/Ncbi/Merge">002161</idno><idno type="wicri:Area/Ncbi/Curation">002161</idno><idno type="wicri:Area/Ncbi/Checkpoint">002161</idno><idno type="wicri:doubleKey">0006-8993:1989:Tremblay L:responses:of:pallidal</idno><idno type="wicri:Area/Main/Merge">005348</idno><idno type="wicri:Area/Main/Curation">004B29</idno><idno type="wicri:Area/Main/Exploration">004B29</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Responses of pallidal neurons to striatal stimulation in monkeys with MPTP-induced parkinsonism</title><author><name sortKey="Tremblay, L" sort="Tremblay, L" uniqKey="Tremblay L" first="L." last="Tremblay">L. Tremblay</name></author><author><name sortKey="Filion, M" sort="Filion, M" uniqKey="Filion M" first="M." last="Filion">M. Filion</name></author><author><name sortKey="Bedard, P J" sort="Bedard, P J" uniqKey="Bedard P" first="P. J." last="Bedard">P. J. Bedard</name></author></analytic><series><title level="j" type="main">Brain research</title><title level="j" type="abbreviated">Brain Res.</title><idno type="ISSN">0006-8993</idno><imprint><date when="1989">1989</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Brain research</title><title level="j" type="abbreviated">Brain Res.</title><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Action Potentials (drug effects)</term><term>Animals</term><term>Apomorphine (pharmacology)</term><term>Basal ganglion</term><term>Brain</term><term>Caudate nucleus</term><term>Central nervous system</term><term>Corpus Striatum (physiopathology)</term><term>Corpus striatum</term><term>Dopamine</term><term>Electric Stimulation</term><term>Electrical stimulus</term><term>Globus Pallidus (drug effects)</term><term>Globus Pallidus (physiopathology)</term><term>MPTP Poisoning</term><term>Macaca fascicularis</term><term>Monkey</term><term>Neurotoxin</term><term>Pallidum</term><term>Parkinson Disease, Secondary (chemically induced)</term><term>Parkinson Disease, Secondary (physiopathology)</term><term>Parkinson disease</term><term>Putamen</term><term>Unit response</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Apomorphine</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Action Potentials</term><term>Globus Pallidus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Corpus Striatum</term><term>Globus Pallidus</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Electric Stimulation</term><term>MPTP Poisoning</term><term>Macaca fascicularis</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Singe</term><term>Noyau gris central</term><term>Corps strié</term><term>Stimulus électrique</term><term>Pallidum</term><term>Noyau caudé</term><term>Putamen</term><term>Décharge unitaire</term><term>Neurotoxine</term><term>Parkinson maladie</term><term>Dopamine</term><term>Apomorphine</term><term>Encéphale</term><term>Système nerveux central</term><term>Pyridine(méthyl-1,phényl-4,tétrahydro-1,2,3,6</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Singe</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Extracellular single unit activity was recorded from neurons of the internal and external pallidal segments, and from «border cells» (Bor) which are part of the nucleus basalis, in 2 cynomolgus monkeys rendered parkinsonian by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). Cell counts showed that at least 90% of the nigral neurons of the compacta-type were degenerated. Electrical stimulation was applied to 3 sites bilaterally in the striatum; one in the caudate nucleus and 2 in the putamen. The results were compared to those obtained in intact monkeys. In the parkinsonians, more neurons of the 3 types responded to ipsilateral stimulation. The difference was even greater for contralateral responses, except in the case of Bor neurons. Greater proportions of the 3 types of neurons also responded to 2 and 3 sites and showed convergent responses to both the caudate nucleus and the putamen</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bedard, P J" sort="Bedard, P J" uniqKey="Bedard P" first="P. J." last="Bedard">P. J. Bedard</name><name sortKey="Filion, M" sort="Filion, M" uniqKey="Filion M" first="M." last="Filion">M. Filion</name><name sortKey="Tremblay, L" sort="Tremblay, L" uniqKey="Tremblay L" first="L." last="Tremblay">L. Tremblay</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004B29 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004B29 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:90-0226454
|texte= Responses of pallidal neurons to striatal stimulation in monkeys with MPTP-induced parkinsonism
}}
| This area was generated with Dilib version V0.6.29. |  |